This tool provides a toxicokinetics-toxicodynamics (TKTD) analysis of bioassay survival data, including descriptive summaries of the data and an estimation of LCx values (x% Lethal Concentration). MOSAICGUTS-fit does not expect any input besides the survival dataset: the service will optimize its parameters automatically.
All calculations are based on a companion R package named MORSE and more details about the underlying modeling can be found in the corresponding vignette and companion research papers.
Jager T, Albert C, Preuss T, Ashauer R. 2011. General Unified Threshold Model of Survival-a Toxicokinetic-Toxicodynamic Framework for Ecotoxicology. Environmental Science and Technology, 45: 2529–2540. URL : http://pubs.acs.org/doi/abs/10.1021/es103092a
Delignette-Muller ML, Ruiz P, Veber P. 2017. Robust fit of toxicokinetic-toxicodynamic models using prior knowledge contained in the design of survival toxicity tests. Environmental Science and Technology, 51: 4038-4045. URL : http://pubs.acs.org/doi/abs/10.1021/acs.est.6b05326.
Baudrot V, Preux S, Ducrot V, Pavé A, Charles S. 2018. New insights to compare and choose TKTD models for survival based on an inter-laboratory study for Lymnaea stagnalis exposed to Cd. Environmental Science and Technology, doi: 10.1021/acs.est.7b05464. URL : http://pubs.acs.org/doi/abs/10.1021/acs.est.7b05464?journalCode=esthag
Jager T, Ashauer R. 2018. Modelling survival under chemical stress. A comprehensive guide to the GUTS framework. Version 1.0. Available from https://leanpub.com/guts_book.